Chest pain that is not explained by reflux disease or cardiac, musculoskeletal, mucosal, or motor esophageal abnormalities is classified as functional chest pain (FCP). Population-based studies reported that the prevalence of NCCP ranges between 19.0–33.0% in the general adult population.
Rome IV Diagnostic Criteria for FCP :
- Retrosternal chest pain or discomfort**
- Absence of associated esophageal symptoms, such as heartburn and dysphagia
- Absence of evidence that gastroesophageal reflux or eosinophilic esophagitis is the cause of the symptom
- Absence of major esophageal motor disorders†
*Criteria fulfilled for the last 3 months with symptom onset at least 6 months prior to diagnosis with a frequency of at least once a week
**Cardiac causes should be ruled out of this
†Achalasia/EGJ outflow obstruction, diffuse esophageal spasm, jackhammer esophagus, absent peristalsis.
Underlying Mechanisms of Functional Chest Pain :
Diagnostics
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